[Download] The Biology of Cancer Weinberg PDF Book 2nd edition
In this blog [Download] The Biology of Cancer Weinberg PDF Book. This includes information spreads through the expression of key experiments which give readers a sense of finding and provides insights into the conceptual foundation underlying modern cancer biology.
About The Biology of Cancer Weinberg PDF Book:
Author: Robert A. Weinberg
About the Author:
Robert A. Weinberg is a founding member of the Whitehead Institute for Biomedical Research. He is the Daniel K. Ludwig Professor for Cancer Research and the American Cancer Society Research Professor at the Massachusetts Institute of Technology (MIT). Dr. Weinberg is an internationally recognized authority on the genetic basis of human cancer and was awarded the U.S. National Medal of Science in 1997.
Author’s Words about The Biology of Cancer Weinberg PDF Book:
Compared with other areas of biological research, the science of molecular oncology is a recent arrival; its beginning can be traced with some precision to a milestone discovery in 1975. In that year, the laboratory of Harold Varmus and J. Michael Bishop in San Francisco, California demonstrated that normal cell genomes carry a gene—they called it a proto-oncogene—that has the potential, following alteration, to incite cancer.
Before that time, we knew essentially nothing about the molecular mechanisms underlying cancer formation; since that time an abundance of information has accumulated that now reveals in outline and fine detail how normal cells become transformed into tumour cells, and how these neoplastic cells collaborate to form life-threatening tumours.
The scientific literature on cancer pathogenesis has grown explosively and today encompasses millions of research publications.
So much information would seem to be a pure blessing. After all, knowing more is always better than knowing less. In truth, it represents an embarrassment of riches. By now, we seem to know too much, making it difficult to conceptualize cancer research as a single coherent body of science rather than a patchwork quilt of discoveries that bear only a vague relationship with one another.
This book is written in a far more positive frame of mind, which holds that this patchwork quilt is indeed a manifestation of a body of science that has some simple, underlying principles that unify these diverse discoveries. Cancer research is indeed a field with conceptual integrity, much like other areas of biomedical research and even sciences like physics and chemistry, and the bewildering diversity of the cancer research literature can indeed be understood through these underlying principles.
About the content:
The second edition of this book is organized, like the first, into 16 chapters of quite different lengths. The conceptual structure that was established in the first edition still seemed to be highly appropriate for the second, and so it was retained. What has changed are the contents of these chapters: some have changed substantially since their first appearance seven years ago, while others—largely early chapters—have changed little.
The unchanging nature of the latter is reassuring since these chapters deal with early conceptual foundations of current molecular oncology; it would be most unsettling if these foundational chapters had undergone radical revision, which would indicate that the earlier edition was a castle built on sand, with little that could be embraced as well-established, unchanging certainties.
The chapters are meant to be read in the order that they appear, in that each builds on the ideas that have been presented in the chapters before it. The first chapter is a condensed refresher course for undergraduate biology majors and pre-doctoral students; it lays out many of the background concepts that are assumed in the subsequent chapters. The driving force of these two editions has been a belief that modern cancer research represents a conceptually coherent field of science that can be presented as a clear, logical progression.
Embedded in these discussions is anticipation that much of this information will one day prove useful in devising novel diagnostic and therapeutic strategies that can be deployed in oncology clinics. Some experiments are described in detail to indicate the logic supporting many of these concepts. You will find numerous schematic drawings, often coupled with micrographs, that will help you to appreciate how experimental results have been assembled, piece by piece, generating the syntheses that underlie molecular oncology.
The goal of The Biology of Cancer Weinberg PDF Book:
Perhaps the most important goal of this book is to enable you to move beyond the textbook and jump directly into the primary research literature. This explains why some of the text is directed toward teaching the elaborate, specialized vocabulary of the cancer research literature, and many of its terms are defined in the glossary. Boldface type
has been used throughout to highlight key terms that you should understand. Cancer research, like most areas of contemporary biomedical research, is plagued by numerous abbreviations and acronyms that pepper the text of many published reports. The book provides a key to deciphering this alphabet soup by defining these acronyms. You will find a list of such abbreviations in the back.
Also contained in the book is a newly compiled List of Key Techniques. This list will assist you in locating techniques and experimental strategies used in contemporary cancer research.
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