[Download] Free Molecular Biology of Cancer PDF Book 4th Edi.
In the blog, you can [Download] Molecular Biology of Cancer PDF Book. Molecular Biology of Cancer PDF Book by Lauren Pecorino is intended for both undergraduate and graduate-level students. The download link is at the end of this article, you can directly go there and Download The Molecular Biology of Cancer PDF Book 4th Edition but it is recommended that before downloading the book you should read about it, to get the most out of the book.
Author: Lauren Pecorino
About the content of the Molecular Biology of Cancer PDF Book:
Molecular Biology of Cancer Mechanisms, Targets, and Therapeutics is intended for both undergraduate and graduate-level students (including medical students) and employees in the pharmaceutical industry interested in learning about how a normal cell becomes transformed into a cancer cell and how this knowledge has been applied to new diagnostics and therapeutics. In a normal cell, signalling pathways detect and respond to changes in the environment and regulate cellular activities. Cells contain many receptors on their membrane that allow a signal from outside the cell (e.g. growth factors) to be transmitted to the inside of the cell.
Signalling pathways are composed of molecules that interact with other molecules, whereby one triggers the next in a sequence, in a way similar to the actions of team members in a relay race. The relay of information may cause a change in cell behaviour or in gene expression, and results in cellular response (e.g. cell growth). Interference in these signal transduction pathways has grave consequences (e.g. unregulated cell growth) and may lead to the transformation of a normal cell into a cancer cell. The identification of the malfunctions of specific pathways involved in carcinogenesis provides scientists with molecular targets that can be used to generate new cancer therapeutics.
The author has chosen to present the biology of cancer together with a promise for its application towards designing new cancer drugs. Therefore, for most chapters in the text, the first half discusses the cell and molecular biology of a specific hallmark of cancer, and the last half of the chapter discusses therapeutic strategies! To help form a link between particular molecular targets discussed in the first half of the chapter and the therapeutic strategies discussed in the last half of the chapter, a target symbol (@) is shown in the margin. The author hopes that this presentation stimulates interest and motivates learning of the subject matter.
Several areas of cancer biology have seen enormous growth over recent years and have been assigned their own chapter in this fourth edition. These include separate chapters for Metastasis, Angiogenesis, Immunology and Immunotherapy, Infectious Agents and Inflammation, Technology and Drug, and Diagnostics Development. New topics have been added. To name a few, these include immune checkpoints, studying gene function by CRISPR-Cas9, mutational signatures (kataegis) caused by APOBEC, newly proposed mechanisms for the role of obesity in cancer, non-coding RNAs, and the role of exosomes in intercellular communication. Most exciting is the numerous additions of newly approved therapeutics to many chapters.
Table of Content:
|Sr. No.||Chapter Name||Page NO.|
|2||DNA structure and stability: mutations versus repair||22|
|3||Regulation of gene expression||53|
|4||Growth factor signalling and oncogenes||79|
|5||The cell cycle||109|
|6||Growth inhibition and tumour suppressor genes||128|
|8||Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukaemia||178|
|11||Nutrient and hormone effects on the genome||245|
|12|| Tumour immunology and immunotherapy||277|
|13||infectious agents and inflammation||302|
|14||Technology and drug and diagnostics development||326|
|APPENDIX 1 CELL CYCLE REGULATION||353|
Features of the new edition :
New to this edition
- Use of full colour and the addition of primary data from the literature.
- Updates of immunology and immunotherapies,
- New topics covered include immune checkpoints, studying gene function by CRISPR-Cas9, mutational signatures (kataegis) caused by APOBEC, non-coding RNAs, newly proposed mechanisms for the role of obesity in cancer, and the role of exosomes in intercellular communication, to name a few.
- Additional “How do we know that?” features.
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